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The 2 kidneys lie outside the peritoneal cavity close to the posterior abdominal wall, 1 on each side of the vertebral column Each of the 2 kidneys is a beanshaped structure The rounded, outer convex surface of each kidney faces the side of the body, and the indented surface, called the hilum, is medial Each hilum is penetrated by a renal artery, renal vein, nerves, and a ureter, which carries urine out of the kidney to the bladder Each ureter within a kidney is formed from funnel-like structures called major calyces, which, in turn, are formed from minor calyces The minor calyces fit over underlying cone-shaped renal tissue called pyramids The tip of each pyramid is called a papilla and projects into a minor calyx The calyces act as collecting cups for the urine formed by the renal tissue in the pyramids The pyramids are arranged radially around the hilum, with the papillae pointing toward the hilum and the broad bases of the pyramids facing the outside, top, and bottom of the kidney (from the 12-o clock to the 6-o clock position) The pyramids constitute the medulla of the kidney Overlying the medullary tissue is a cortex, and covering the cortical tissue on the very external surface of the kidney is a thin connective tissue capsule (Figure 1 1) The working tissue mass of both the cortex and medulla is constructed almost entirely of tubules (nephrons and collecting tubules) and blood vessels (capillaries and capillary-like vessels) Tubules and blood vessels are intertwined (something like a plateful of spaghetti) or arranged in parallel arrays (like bundles of soda straws) and, in either case, are always close to each other Between the tubules and blood vessels lies an interstitium, which comprises less than 10% of the renal volume The interstitium contains fluid and scattered interstitial cells (fibroblasts and others) that synthesize an extracellular matrix of collagen, proteoglycans, and glycoproteins The cortex and medulla have very different properties both structurally and functionally On closer examination, we see that (1) the cortex has a highly granular appearance, absent in the medulla, and (2) each medullary pyramid is divisible into an outer zone (adjacent to the cortex) and an inner zone, which includes the papilla All these distinctions reflect the arrangement of the various tubules and blood vessels.

Electrochemical experiments fall into two broad categories Some experiments are concerned with standard cell voltages, while other experiments use the Nernst equation directly or indirectly Experiment 21 in the Experimental chapter uses these concepts Measurements of the cell potential are essential and require a voltmeter (potentiometer) These measurements may be taken from different combinations of half-cells, or from measurements before and after changes of some aspect of the cell were made Using measurements of different half-cell combinations, a set of standard reduction potentials may be constructed This set will be similar to a table of standard reduction potentials The solutions used in the half-cells must be of known concentration These solutions are produced by weighing reagents and diluting to volume The measurements will require a balance and a volumetric flask It is also possible to produce known concentrations by diluting solutions This method requires a pipette and a volumetric flask Review the Solutions and Colligative Properties chapter for solution techniques Experiments involving the Nernst equation are primarily concerned with concentrations One or more of the concentrations in the Q portion of the Nernst equation are calculated by measuring the nonstandard cell potential and comparing this to the standard cell potential Remember, you calculate the concentration from a measured voltage Once the concentration is determined, it may be combined with other concentrations and used to calculate an equilibrium constant

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reNaL FUNCtIONS, aNatOMY, aND BaSIC prOCeSSeS / 5

As specified in Section 631, a primary payload is either a sequence of encoded voice subframes or a single SID subframe The encoded voice subframe consists of one or more audio frames containing sample intervals or frames The sample intervals or frames are placed sequentially in an encoded voice subframe If the number of sample intervals or frames in a payload is more than one, the next interval or frame starts on the next octet after the previous interval or frame PAD octets are only used in the last word of the payload if needed for word alignment

Reabsorption is a 2-step process: lumen to interstitium, and interstitium to peritubular capillary Flux from lumen to interstitium can be transcellular, using separate transport steps in the apical and basolateral membranes, or paracellular, around the cells through tight junctions Channels and transporters promote the transmembrane flux of solutes that cannot permeate lipid bilayers Osmotic gradients drive a volume flux across membranes and epithelia

1 Be sure your units cancel to give the unit wanted in your final answer 2 Be sure to round your answer off to the correct number of significant figures 3 Remember that oxidation is the loss of electrons and reduction the gain, and that in redox reactions the same number of electrons is lost and gained 4 Be sure that what you determine to be the oxidizing and reducing agents are reactant species

NOTE: For a G729 single interval (10 ms), the payload contains 2 octets of PAD (see Figure 6-21) If two intervals are included in the payload, the second frame starts from octet 11 The total number of octets with two intervals in a payload is 20 No PAD octets are required (see Figure 6-22 with M 2) The fields in the header of primary payload frames are specified as follows:

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